INTRISIC PATHWAY: anti-apoptosis that inhibits BAX and BAK (part of the BCL-2 family) that are pro-apoptosis. Form a chain that leads to the release of cytochrome c, that associates with proteins, forming the Apoptosome.
major effector in the apoptotic program that orchestrate all the morphologic changes. They are post-translationally regulated pro-caspase ligation active